The article highlights how the Twelve Nidanas of dependent origination can apply to the development and perpetuation of a lack of compassion. Ignorance, mental formations, consciousness, and name and form are the first four links that contribute to the formation of habitual patterns of indifference or lack of concern towards others. The remaining links, including craving, clinging, becoming, birth, and old age and death, reinforce these patterns and perpetuate the cycle of apathy.

To break this cycle of lack of compassion, the article suggests several practices such as cultivating positive mental formations by practicing compassion towards oneself and others, developing awareness of habitual patterns of mind, practicing mindfulness, and letting go of attachment to indifference. By developing an identity based on kindness and compassion towards others, one can create positive change and break the cycle of apathy.