Lets use the example of a person experiencing rumination on regret to illustrate the Twelve Nidanas of dependent origination.
1. Ignorance (avijja): The person lacks understanding of the true nature of reality, including the nature of regret as a mental affliction that arises and ceases in dependence upon causes and conditions.
2. Mental formations (sankhara): Due to ignorance, the person forms habitual patterns of dwelling on past mistakes and missed opportunities.
3. Consciousness (viññana): The persons consciousness is conditioned by these mental formations, making them prone to rumination on regret.
4. Name and form (nama-rupa): The persons body and mind manifest in a way that is susceptible to regret and self-blame.
5. The six sense bases (salayatana): The persons sense organs interact with the external world, bringing to mind past events that trigger feelings of regret.
6. Contact (phassa): The person encounters past experiences through their senses, bringing up past mistakes and missed opportunities.
7. Feeling (vedana): The person experiences an unpleasant feeling as a result of the contact with the past events, which triggers rumination on the feeling of regret.
8. Craving (tanha): The person develops a desire to change the past or alleviate the feeling of regret in the present, often leading to unskillful behaviors such as self-blame or projecting blame onto others.
9. Clinging (upadana): The persons attachment to regret and self-blame intensifies, perpetuating the cycle of rumination.
10. Becoming (bhava): This clinging to regret reinforces the persons habitual patterns and karmic tendencies, leading to further suffering.
11. Birth (jati): The persons rumination on regret manifests in the form of negative self-talk, depression or anxiety, or a loss of confidence, which perpetuates the cycle of mental formations and karmic consequences.
12. Old age and death (jara-marana): The persons attachment to regret and self-blame can lead to physical, mental, and emotional suffering and perpetuate negative consequences in future situations or even future lives.

In this example, we can see how the Twelve Nidanas apply to the arising and perpetuation of rumination on regret. However, its important to note that through the practice of mindfulness meditation, one can recognize the impermanent and interdependent nature of regret and cultivate a sense of acceptance, self-forgiveness, and present-moment awareness, ultimately leading to spiritual progress and liberation.

How to break cycle at each point:

To break the cycle of rumination on regret, one could use various practices and techniques at different points in the cycle:
1. Ignorance: One could work on cultivating insight and understanding through meditation and study of Buddhist teachings, including the Four Noble Truths and the nature of impermanence and interdependence.
2. Mental formations: One could develop new patterns of thought and behavior through mindfulness practices, cognitive-behavioral therapy, or other forms of psychotherapy.
3. Consciousness: By practicing meditation and mindfulness, one can develop an awareness of their patterns of thought and behavior, allowing them to interrupt unhelpful thought patterns before they escalate into full-blown ruminations on regret.
4. Name and form: While there may not be much that can be changed about ones physical and psychological makeup, one can cultivate a sense of acceptance and self-compassion that can help reduce the intensity of feelings of regret.
5. The six sense bases: One can develop mindful awareness of sensory experiences, using senses like touch, sights or sounds to ground oneself in the present moment and avoid getting caught up in past regrets.
6. Contact: One could redirect their attention away from stimuli that trigger feelings of regret, by practicing mindfulness and focusing on present-moment reality.
7. Feeling: By practicing mindfulness, self-compassion, and acceptance, one can develop a less reactive response to negative feelings, reducing the potential for craving.
8. Craving: By noticing and accepting feelings of sadness or regret that arise and acknowledging that they are a natural part of the human experience, one can reduce the potential for craving.
9. Clinging: Through cultivation of mindfulness, self-compassion, and cognitive-behavioral techniques, one can reduce the intensity of attachment to regretful thoughts.
10. Becoming: By intentionally engaging in healthy patterns of thought and behavior and reframing negative experiences in a positive light, one can foster new karmic habits that lead to a reduction in rumination on regret.
11. Birth: By identifying and interrupting habitual patterns of rumination on regret, one can reduce the intensity of negative self-talk and other symptoms of suffering.
12. Old age and death: Through practicing mindfulness, self-compassion, and insight, one can develop an acceptance of impermanence and death, reducing the potential for suffering at the end of life.