Let us use the example of a person experiencing self-loathing to illustrate the Twelve Nidanas of dependent origination:
1. Ignorance (avijja): The person lacks understanding of the true nature of reality and the interconnectedness of all phenomena, including the true nature of the self.
2. Mental formations (sankhara): Due to ignorance, the person has formed habitual patterns of negative self-talk and self-doubt.
3. Consciousness (viññana): The persons consciousness is conditioned by these mental formations, making them prone to self-loathing.
4. Name and form (nama-rupa): The persons body and mind manifest in a way that is susceptible to negative self-concept and self-loathing.
5. The six sense bases (salayatana): The persons sense organs interact with the external world.
6. Contact (phassa): The person encounters a situation that triggers their feelings of inadequacy or self-hatred, such as making a mistake or receiving criticism.
7. Feeling (vedana): The person experiences an unpleasant feeling as a result of the contact with the triggering situation.
8. Craving (tanha): The person develops a desire to change their perceived flaws or escape the suffering caused by their self-loathing.
9. Clinging (upadana): The persons attachment to their self-loathing intensifies, and they cling to their negative self-concept and habitual patterns of thought, further driving the cycle of suffering.
10. Becoming (bhava): This clinging to self-loathing reinforces the persons sense of self and perpetuates the cycle of negative mental formations and karmic tendencies.
11. Birth (jati): The persons self-loathing manifests in the form of self-destructive behaviors, further perpetuating the cycle of negative habits and consequences.
12. Old age and death (jara-marana): The persons unaddressed self-loathing can lead to physical, mental, and emotional suffering and negative consequences in future situations or lifetimes.
In this example, we can see how the Twelve Nidanas apply to the arising and perpetuation of self-loathing. By understanding the dependent origination of self-loathing and recognizing the interdependence of the Twelve Links, a person can cultivate self-compassion and work towards breaking the cycle of negative self-talk and habitual patterns, ultimately leading to greater peace and liberation from suffering.

How to break cycle at each point:

To break the cycle of self-loathing at each point of the Twelve Nidanas:

1. Ignorance (avijja): Develop a greater understanding of the inherent value and self-worth of all beings by studying Buddhist teachings and cultivating self-compassion.
2. Mental formations (sankhara): Develop positive self-talk, notice when engaging in harmful self-criticism and practice tools to interrupt negative and habitual patterns of thinking.
3. Consciousness (viññana): Develop a non-judgmental awareness of thoughts and feelings, using mindfulness practices to observe without attachment or aversion.
4. Name and form (nama-rupa): Shift the focus away from identification with the body and mind, exploring the nature of impermanence, non-self, and emptiness, and cultivating a deeper sense of connection to all beings.
5. The six sense bases (salayatana): Practice restraint of the senses and avoid environments and situations that trigger negative mental formations and self-loathing.
6. Contact (phassa): Practice responding to triggering situations with loving-kindness and compassion, reframing negative self-talk, and alter behavior that lead to negative feedback from others.
7. Feeling (vedana): Practice cultivating equanimity towards pleasant, unpleasant, or neutral feelings, knowing that the feelings are impermanent and not-self.
8. Craving (tanha): Gradually reducing desire and attachment towards pleasant feelings and aversion towards unpleasant feelings, practicing mindfulness and insight meditation techniques to observe them in a non-judgmental and non-reactionary way.
9. Clinging (upadana): Practice non-attachment to objects of craving, avoiding identifying with negative self-talk and cultivating positive self-reinforcement mantras.
10. Becoming (bhava): Practice setting an intention to create positive karmic potential through virtuous actions, including those related to how one views and treats themselves.
11. Birth (jati): Practice being kind to oneself, avoid self-destructive behaviors, cultivating positive habits that reinforce positive self-talk.
12. Old age and death (jara-marana): Practice viewing moments of suffering as opportunities to strengthen ones resolve towards cultivating self-compassion and positive thinking habits.

In conclusion, breaking the cycle of self-loathing is an ongoing practice that involves cultivating a deep understanding of oneself, observing and interrupting negative thinking patterns, and developing positive habits of thinking and behavior. Applying the principles of dependent origination to ones practice can offer a powerful framework for recognizing the interconnectedness of all things and the possibility for liberation from suffering.